The busy motorway will again be closed in both directions between junctions 9 (A243 Leatherhead) and 10 (A3 Wisley) from 9pm Friday, May 10 to 6am Monday, May 13.
A 19-mile diversion route will be in place which uses the A3 and the A243.
National Highways says that it expects long delays and is urging drivers to only travel if necessary.
Drivers using the signed diversion route will not be subject to any Ultra Low Emission Zone (ULEZ) charges that may usually apply.
The ULEZ, however, will remain in force on all other routes in London across the weekend.
Diversion routes:
Diversion route clockwise for all but over-height vehicles:
Leave M25 at junction 8, A217 (Reigate). Follow the A217 London, Sutton, (A240) Kingston. After 3½ miles turn left onto the A240 Epsom, Kingston. After 3 miles at the Esso roundabout, turn right onto the A24 (A240) Kingston. Continue for 3 miles and turn left onto the A3 Portsmouth, Guildford. Continue for 9½ miles to the M25 and re-join the motorway at junction 10.
Diversion route anticlockwise for all but over-height vehicles:
Leave M25 at junction 10 to join the A3 towards London. After 9½ miles at the Hook interchange leave the A3 turning right onto the A240 Epsom, Reigate. Continue for 3 miles to the Esso roundabout and turn left onto the A240 Reigate. Continue for 3 miles then turn right onto the A217 Reigate, M25. After 3½ miles turn left to re-join the M25 motorway at junction 8.
Diversions will be in place from junction eight, sending drivers on a 20-mile route via Epsom, Surbiton and Cobham. A different route will be in place for taller vehicles such as lorries.
Drivers could face reduced capacity – and potentially increased congestion – between junctions five and seven on the same weekend.
Details obtained at https://nationalhighways.co.uk/our-roads/south-east/m25-junction-10/